Rabies virus immunity in genetically selected high- and low-responder lines of mice
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Rabies virus immunity in genetically selected high- and low-responder lines of mice.
The antibody responsiveness to and the specific vaccination effect of rabies virus infection were investigated in high- and low-responder lines of mice produced by two-way selective breedings for quantitative production of antibodies to flagellar (H/f and L/f lines) or somatic (H/s and L/s lines) antigens of salmonellae. After specific immunization, both high lines were more resistant to rabies...
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The immune response to certain synthetic polypeptide antigens and native proteins has been shown to be controlled by immune response (Ir) genes, which reside in the murine major histoeompatibility complex (MHC) 1 (reviewed in 1). The expression of such Ir gene control has been localized to T cells, B cells, and/or antigen-presenting cells (2-4). Support for the concept of Ir gene expression in ...
متن کاملSerum Concentrations and Allotypes of Immuno-globulins in Two Lines of Mice Genetically Selected for "high" or "low" Antibody Synthesis
Random-bred Swiss mice were selectively bred for 16 generations; selection was based on their agglutinin response to sheep and pigeon erythrocytes to produce a high and a low responder line. The serum levels of individual immunoglobulins differed significantly in these two lines before immunization. The differences in the levels of immunoglobulins were much more marked after immunization with p...
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Two lines of mice have been separated by selective breeding for the character "agglutinin production to heterologous erythrocytes." Around the 18th generation of selection the two lines could be considered as homozygous for the character investigated. This trait is under the control of a group of additive genes. The interline difference in the production of anti-SE agglutinins was verified for ...
متن کاملRabies infection and specific effect of vaccination in mice selected for high and low immunobiological parameters.
Innate and acquired resistance to rabies infection was investigated in mice genetically selected for high (H) or low (L) antibody responsiveness from selections I, III and IV and in mice selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction. These mouse lines were infected intramuscularly with different virus dilutions and the LD50 was determined. The HIII and HIV mouse ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1979
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.25.1.23-26.1979